NF-kB Feedback Response
Gene co-expression module in CD4⁺ T cells
| Category | TCR/AP1/NFKb pathway |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
Hubs PPP1R15B (GADD45 partner, eIF2alpha regulation), TNFAIP3 (A20), NFKBIZ, ATF3, XBP1, CSRNP1, TIPARP, RASGEF1B. Combines NF-kB negative feedback (TNFAIP3, NFKBIZ) with stress/IEG response (ATF3, CSRNP1) and UPR (XBP1, PPP1R15B). Neighbor of M82 (AP-1) and M76 (UPR), bridging NF-kB activation and integrated stress response. NF-kB feedback is the dominant theme.
Genes
ADGRE5, ARL5B, ATF3, CSRNP1, NFKBIZ, PPP1R15B, RASGEF1B, TIPARP, TNFAIP3, XBP1, ZFAND5
Most correlated modules
- Immediate Early AP-1 · correlation 0.84
- Unfolded Protein Response · correlation 0.81
- Resting memory T cell · correlation 0.70
- Cytokine signaling · correlation 0.67
- NF-kB activation · correlation 0.65
- Integrated Stress Response · correlation 0.62
- Effector activation NFkB · correlation 0.60
- Cytotoxic Effector CD4 · correlation 0.60
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.