MAPK feedback signaling
Gene co-expression module in CD4⁺ T cells
| Category | TCR/AP1/NFKb pathway |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes DUSP16, DUSP4 (MAPK phosphatases), PIM2, PELI1 (Pellino E3 ligase, TLR/IL-1 signaling), BACH1, EPSTI1 are markers of T cell activation and NF-kB/MAPK signaling output. DUSP4/DUSP16 are classic negative feedback regulators downstream of TCR/AP1 signaling. EPSTI1 is interferon-inducible. Module is strongly inflammation-associated and reverses with treatment, consistent with an activation-driven negative-feedback program. Best fits TCR/AP1/NFKb pathway.
Genes
BACH1, DUSP16, DUSP4, E2F3, EPSTI1, MAT2B, PELI1, PIM2, SEC14L1, ZBTB38, ZC3H7A
Most correlated modules
- NF-kB feedback · correlation 0.93
- Activated effector Tcell · correlation 0.91
- mRNA stability regulation · correlation 0.91
- Activated Treg · correlation 0.88
- Cell cycle regulators · correlation 0.88
- Regulatory T cell · correlation 0.87
- Inflammatory activation · correlation 0.85
- Th1 IL12 response · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.