Chromatin regulation
Gene co-expression module in CD4⁺ T cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 21 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 21 genes have a known function matching the annotation |
Why this annotation
Hub genes are chromatin/transcription regulators and RNA processing: EP300, KAT6A (acetyltransferases), PHF3, TOX4, MIER1, ANKRD11 (chromatin), SLU7, RBM6, PAPOLA, SLTM (splicing/polyadenylation), IRF2 (transcription factor). Predominantly nuclear gene-expression regulation; chromatin/transcription program.
Genes
ANKRD11, BIRC6, CNTRL, EP300, FAM118A, GOLGA4, IRF2, KAT6A, MIER1, PAFAH1B1, PAPOLA, PHF3, PRRC2C, RBM6, SLTM, SLU7, SPTAN1, TCF25, TOX4, USP8, ZNF207
Most correlated modules
- RNA & Chromatin Regulation · correlation 0.91
- Epigenetic regulation · correlation 0.87
- PD-L1 checkpoint · correlation 0.83
- Oxidative phosphorylation · correlation 0.81
- Glycosylation & trafficking · correlation 0.78
- Chromatin Regulation · correlation 0.77
- Effector Immune Activation · correlation 0.76
- Integrin Adhesion Migration · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.