PSMD13 — Proteasome 26S subunit, non-ATPase 13

PSMD13 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

PSMD13's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Oxidative Phosphorylation Mitochondrial & OxPhos	AP2S1, ATP5F1C, ATP5PF, COPS9, COX6B1, EID1, FAM89B, FDPS +19 more	View in SCUBA
CD8⁺ T cells	Proteostasis Translation Protein processing & ER	BZW1, CCT5, CCT7, EIF2S2, HNRNPC, HNRNPM, MDH1, PCBP1 +3 more	View in SCUBA
Endothelial	Rho-Actin Remodeling Cytoskeletal	ANAPC11, ARPC2, ARPC5, ATP6V0B, GNAI2, HNRNPH3, HRAS, KIF5B +9 more	View in SCUBA
Gamma-delta T cells	S-phase Proliferation Cell cycle	ANKRD9, BCL6, COPS3, DCXR, ERRFI1, GMNN, GOLIM4, MTHFD2 +6 more
Innate lymphoid cells	TRiC Chaperonin Folding Protein processing & ER	ATP6V0D1, CACYBP, CCT2, CCT3, CCT4, CCT5, EIF5A, ELOC +9 more	View in SCUBA
Macrophages	Proteasome UPS Housekeeping	ATP6V1D, ATP6V1E1, BAX, C1orf43, COX7A2L, DCUN1D5, DNAJC15, DNAJC8 +28 more	View in SCUBA

About the gene

Synonyms	p40.5, Rpn9
Chromosome	11: 236966-252984
Predicted location	Intracellular
Essential gene	Yes
Protein class	Essential proteins, Predicted intracellular proteins

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.