NUTF2 — Nuclear transport factor 2
NUTF2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NUTF2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Mitochondrial Translation Mitochondrial & OxPhos | ARF5, CBX6, CCDC124, CISD3, DCTN2, DDA1, EIF4E2, FKBP3 +17 more | View in SCUBA |
| CD8⁺ T cells | Glycolysis Program Housekeeping | ADRM1, CSNK2B, ENO1, MTHFD2, P4HB, PGAM1, PKM, POLR2E +6 more | View in SCUBA |
| Innate lymphoid cells | ILC1 Inflammatory Activation Inflammation | ALOX5AP, CNOT7, COMMD10, ELAVL1, FKBP8, FNTA, IFI27L2, IL32 +11 more | View in SCUBA |
| Macrophages | Proteasome UPS Housekeeping | ACP1, ARPC5L, ATP6V1G1, AURKAIP1, C19orf53, CHMP2A, CIAO2B, CIB1 +31 more | View in SCUBA |
About the gene
| Synonyms | NTF2, PP15 |
|---|---|
| Chromosome | 16: 67846882-67872567 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Plasma proteins, Predicted intracellular proteins |
| Biological process | mRNA transport, Protein transport, Translocation, Transport |
Function
Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.