POLR2E — RNA polymerase II, I and III subunit E

POLR2E belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

POLR2E's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Nucleotide Metabolism Biosynthesis Mitochondrial & OxPhos	ATIC, ATP5MC1, C1QBP, CCT7, DCTPP1, EBNA1BP2, EEF1E1, EIF5A +13 more	View in SCUBA
CD4⁺ T cells	Respiratory chain assembly Mitochondrial & OxPhos	COA4, COA6, CYC1, EBNA1BP2, ERCC1, PRELID3B, PSMD3, VMA21	View in SCUBA
CD8⁺ T cells	Glycolysis Program Housekeeping	ADRM1, CSNK2B, ENO1, MTHFD2, NUTF2, P4HB, PGAM1, PKM +6 more	View in SCUBA
Endothelial	Mitochondrial OxPhos Mitochondrial & OxPhos	ARPC1B, ATP5MF, AURKAIP1, NDUFB2, NDUFS6, PARVB, PFN1, SERF2 +3 more	View in SCUBA
Gamma-delta T cells	Cellular Homeostasis Housekeeping	ANAPC11, BANF1, CALM3, CBX3, CBX5, COMMD4, DPM2, DUT +21 more
Innate lymphoid cells	Cellular Metabolic Maintenance Metabolism	ADIPOR1, APH1A, ARF5, BCAP31, CLIC1, CSNK2B, CYB5R3, DHPS +13 more	View in SCUBA
Macrophages	ERAD Proteasome Housekeeping	ADRM1, EIF6, EMC6, GLRX3, GNPTG, LRPAP1, MAP2K2, MED8 +16 more	View in SCUBA
Mucosal-associated invariant T cell	RNA Biogenesis & Folding Housekeeping	ADH5, CCT3, CTDSP1, FAM117A, FKBP1A, FKBP8, LSM4, MAT2B +6 more

About the gene

Synonyms	hRPB25, hsRPB5, RPABC1, RPB5, XAP4
Chromosome	19: 1086574-1095380
Predicted location	Intracellular
Essential gene	Yes
Protein class	Essential proteins, Metabolic proteins, Predicted intracellular proteins, RNA polymerase related proteins
Biological process	Host-virus interaction, Transcription

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPABC1 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.