RSL1D1 — Ribosomal L1 domain containing 1
RSL1D1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RSL1D1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Ribosome biogenesis Housekeeping | APEX1, APRT, C1QBP, CCDC59, HNRNPA1, IMPDH2, LBH, LDHA +17 more | View in SCUBA |
| Gamma-delta T cells | Translation & Proteostasis RNA processing & translation | ARAP2, ATG13, BRPF1, CLINT1, CRKL, E2F3, EEF2, EIF2AK2 +15 more | |
| Hematopoietic progenitor cells | Biosynthetic Housekeeping Housekeeping | BZW2, CHST12, CREG1, EEF1B2, FBL, HNRNPA1, HSP90AB1, IMPDH2 +7 more | |
| Macrophages | Ribosome Biogenesis Housekeeping | ABCE1, BCCIP, CLPX, COX20, DDX18, DUS1L, EIF3B, IDH3A +17 more | View in SCUBA |
About the gene
| Synonyms | CSIG, DKFZP564M182, L12, PBK1, UTP30 |
|---|---|
| Chromosome | 16: 11833850-11851580 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins, Ribosomal proteins |
Function
Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.