mRNA Stability & Splicing
Gene co-expression module in Innate lymphoid cells
| Category | RNA processing & translation |
|---|---|
| Genes | 15 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes include BUD31 (splicing factor, spliceosome), HSPA9 (mortalin/GRP75, mitochondrial chaperone/stress), PABPC1 (poly(A)-binding protein cytoplasmic 1, mRNA stability/translation), SRSF6 (serine/arginine-rich splicing factor 6), RBM39 (RNA-binding motif protein 39, splicing), RBMX (RNA-binding motif X-linked, splicing), GNAI3 (G protein alpha i3, signal transduction), EIF4G2 (eukaryotic translation initiation factor 4G2, translation), TAF7 (TFIID subunit, transcription), PAIP2 (poly(A)-binding protein interacting protein 2, translation regulation), PRKAR1A (protein kinase A regulatory subunit, cAMP signaling), PAPOLA (poly(A) polymerase alpha, mRNA polyadenylation), PABPC4 (poly(A)-binding protein cytoplasmic 4, mRNA stability), TAF1D (TAFI48, RNA Pol I transcription), TOB2 (transducer of ErbB2, mRNA deadenylation/anti-proliferative). The module has a strong theme of mRNA metabolism: polyadenylation (PAPOLA), poly(A)-binding (PABPC1, PABPC4, PAIP2), deadenylation (TOB2), splicing (BUD31, SRSF6, RBM39, RBMX), and translation initiation (EIF4G2). This is a coherent mRNA processing/stability module. HSPA9 and GNAI3 are outliers. Neighbor context of RNA processing modules strongly supports this.
Genes
BUD31, EIF4G2, GNAI3, HSPA9, PABPC1, PABPC4, PAIP2, PAPOLA, PRKAR1A, RBM39, RBMX, SRSF6, TAF1D, TAF7, TOB2
Most correlated modules
- Mitochondrial Housekeeping · correlation 0.89
- Integrated Stress Response · correlation 0.89
- RNA Processing & Proteostasis · correlation 0.88
- Pyruvate Metabolism · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.