Proteasome & TCA
Gene co-expression module in Innate lymphoid cells
| Category | Protein processing & ER |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 14 genes have a known function matching the annotation |
Why this annotation
PSMD2 and PSMD4 are core 26S proteasome regulatory subunits (19S lid), making proteasomal degradation a central theme. MDH2 (malate dehydrogenase) and SUCLG1 (succinyl-CoA ligase) are TCA cycle enzymes; NDUFA1 is Complex I (NADH dehydrogenase). HDAC1 and PRMT1 are epigenetic regulators (histone deacetylase and arginine methyltransferase). CLTA (clathrin) and ARPC5L/CAPZA1 (Arp2/3 and actin capping) suggest vesicle trafficking and cytoskeletal dynamics. Strong coherence supports a genuine program; the dominant theme is ubiquitin-proteasome system combined with mitochondrial TCA metabolism, consistent with protein quality control in metabolically active ILC1 cells.
Genes
ACP1, ARPC5L, CAPZA1, CLTA, COPS9, HDAC1, MDH2, NDUFA1, NUDT16L1, PRMT1, PSMD2, PSMD4, SUCLG1, TERF2IP
Most correlated modules
- Proteasome & COPI Trafficking · correlation 0.96
- mTOR Metabolic Stress · correlation 0.94
- Mitochondrial OxPhos Biogenesis · correlation 0.94
- Actin Cytoskeleton Dynamics · correlation 0.94
- Lipid & Isoprenoid Metabolism · correlation 0.94
- Mixed Proteostasis Metabolism · correlation 0.94
- ILC1 Cytoskeletal Metabolic · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.