Cytokine-driven Activation
Gene co-expression module in Innate lymphoid cells
| Category | activation |
|---|---|
| Genes | 11 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
Strong coherence, enriched in res_ILC3 and ILC1. SOCS3 (core) is a canonical feedback inhibitor of JAK-STAT signaling induced by cytokines like IL-6, IL-10, and IL-22. BIRC3 (core) is an NF-κB target anti-apoptotic gene. CD69 (strong) is the earliest surface activation marker. DUSP5 (strong) is a MAPK phosphatase induced by ERK activation. ISG15 (moderate) is an interferon-stimulated gene. CALR (core) is an ER chaperone involved in stress and antigen presentation. GADD45G is a stress-response gene. RUNX3 is an NK/ILC transcription factor. Together, SOCS3+BIRC3+CD69+DUSP5 define a cytokine-driven early activation program with negative feedback. Strong delta_inflammation confirms inflammatory context.
Genes
BIRC3, CALR, CD69, DUSP5, GADD45G, ISG15, NCOA7, PPIF, RUNX3, SOCS3, VMP1
Most correlated modules
- Transcriptional Activation · correlation 0.87
- NF-κB Inflammatory Activation · correlation 0.86
- RNA Chromatin Regulation · correlation 0.85
- NK Cytokine Signaling · correlation 0.85
- Integrated Stress Response · correlation 0.84
- Heat Shock Response · correlation 0.84
- Immediate Early Response · correlation 0.83
- IFN-gamma Response · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.