Immediate Early Response
Gene co-expression module in Innate lymphoid cells
| Category | activation |
|---|---|
| Genes | 17 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes FOSB, NR4A1, EGR1, ATF3, BTG2, and IRF1 are canonical immediate-early genes (IEGs) induced rapidly upon cellular activation or stress. PLK3 is a stress-activated kinase. DNAJA1 is a co-chaperone co-induced with IEGs. SRSF7, DDX3X, EIF5, EIF4A3 represent co-regulated RNA processing machinery. The module is core coherence, tightly co-regulated, and significantly upregulated in inflammation. This is a classic immediate-early transcriptional response program.
Genes
ATF3, BRD2, BTG2, CCNL1, DDX3X, DNAJA1, EGR1, EIF4A3, EIF5, FOSB, IRF1, NR4A1, PLK3, PPP1R10, SRSF7, UBE2S, ZC3HAV1
Most correlated modules
- ILC3 Transcriptional Identity · correlation 0.95
- mTOR Stress Response · correlation 0.92
- Transcriptional Activation · correlation 0.90
- Heat Shock Response · correlation 0.86
- NK Cytokine Signaling · correlation 0.86
- NF-κB Inflammatory Activation · correlation 0.85
- Cytokine-driven Activation · correlation 0.83
- Integrated Stress Response · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.