Dissociation Stress Response
Gene co-expression module in Innate lymphoid cells
| Category | Stress |
|---|---|
| Genes | 18 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 18 genes have a known function matching the annotation |
Why this annotation
The module has moderate coherence with many weakly-associated genes. Hub genes include IER2 (immediate early/dissociation stress), TUBA1B (cytoskeletal stress), NDRG1 (hypoxia/stress response), PRDX1 (redox stress), YME1L1 (mitochondrial protease), and CALM2 (calcium signaling). The combination of immediate early response, cytoskeletal, redox, and metabolic stress genes with predominantly weak module memberships is characteristic of dissociation-induced cellular stress rather than a coherent in vivo program. TNF and RGS16 are weakly associated and likely reflect spillover from the neighboring M98 inflammatory module. The ILC1 enrichment for several genes may reflect that ILC1s are more susceptible to dissociation stress or represent a minor ILC1-specific activation signal.
Genes
C12orf57, CA2, CALM2, EHD1, EIF4A2, IER2, MEPCE, NDRG1, NUDT4, PRDX1, RGS16, SLC20A1, TENT5A, TMEM107, TNF, TUBA1B, WDR74, YME1L1
Most correlated modules
- ILC3 Transcriptional Identity · correlation 0.86
- NK Cytokine Signaling · correlation 0.85
- Heat Shock Response · correlation 0.84
- Immediate Early Response · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.