SRSF6 — Serine and arginine rich splicing factor 6
SRSF6 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SRSF6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Innate lymphoid cells | mRNA Stability & Splicing RNA processing & translation | BUD31, EIF4G2, GNAI3, HSPA9, PABPC1, PABPC4, PAIP2, PAPOLA +6 more | View in SCUBA |
| Macrophages | Pre-mRNA Splicing Housekeeping | BCLAF1, CSNK1A1, DDX3X, DDX5, EWSR1, FUS, HNRNPH1, HNRNPH3 +11 more | View in SCUBA |
| Mucosal-associated invariant T cell | Co-transcriptional Splicing RNA processing & translation | C9orf78, CCDC85C, CCNK, CDKN1B, DNTTIP2, EIF4B, ILF3, LAPTM5 +16 more |
About the gene
| Synonyms | B52, SFRS6, SRP55 |
|---|---|
| Chromosome | 20: 43457893-43466046 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | Repressor, RNA-binding |
| Biological process | mRNA processing, mRNA splicing |
Function
Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre- mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.