DYNC1I2 — Dynein cytoplasmic 1 intermediate chain 2
DYNC1I2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DYNC1I2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Innate lymphoid cells | RNA Splicing Processing RNA processing & translation | ATP5F1C, CHMP2A, CHMP4A, CYBA, DSTN, DYNLRB1, FKBP3, LSM3 +16 more | View in SCUBA |
| Lymphatic endothelial | Glycolytic Housekeeping Housekeeping | CALCOCO2, CANX, CAP1, DPYSL2, EIF2S2, ENO1, GIMAP8, PGAM1 +1 more | View in SCUBA |
| Mucosal-associated invariant T cell | Mitochondrial Ribosome Mitochondrial & OxPhos | AGTRAP, BRK1, C11orf68, C14orf119, CNPY2, CZIB, DCTPP1, FOXN2 +22 more |
About the gene
| Synonyms | DIC74, DNCI2 |
|---|---|
| Chromosome | 2: 171687409-171750158 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Motor protein |
| Biological process | Host-virus interaction, Transport |
Function
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1 (By similarity). Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.