NCOA1 — Nuclear receptor coactivator 1
NCOA1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NCOA1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | mRNA stability regulation Immune regulation | APLP2, ARID5B, CARHSP1, GK, GLCCI1, GRAMD4, HIVEP1, METTL8 +12 more | View in SCUBA |
| Gamma-delta T cells | Effector Cytokine Secretion Inflammation | APBA2, ASPH, CCL3, CCL4, CMC1, CYRIA, DTHD1, DTNBP1 +25 more | |
| Lymphatic endothelial | Chromatin Remodeling DNA/chromatin regulation | DYRK1A, HERC1, KDM6A, KMT2C, MBNL1, MED13L, MRTFA, PDE8A +2 more | View in SCUBA |
| Macrophages | Rho GTPase Signaling Cytoskeletal | ABHD18, AFF1, ARHGEF7, DIP2B, DNAAF9, DOCK11, EVI5, GNAQ +24 more | View in SCUBA |
| Neutrophils | ER Stress Response Stress | ATF6, DISC1, GRB10, KIAA0825, MAP2K4, PACS1, TMCC1 |
About the gene
| Synonyms | bHLHe74, F-SRC-1, KAT13A, NCoA-1, RIP160, SRC1 |
|---|---|
| Chromosome | 2: 24491254-24770702 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, Acyltransferase, Transferase |
| Biological process | Transcription, Transcription regulation |
Function
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone- dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.