SETD5 — SET domain containing 5
SETD5 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SETD5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Centrosome Organization DNA/chromatin regulation | AKAP9, ARMCX6, CCNT2, CEP350, CUL5, DDHD1, DDX42, DENND6A +23 more | |
| Lymphatic endothelial | ZEB1-driven EMT endothelial development | ASH1L, CUX1, ERBIN, ITSN2, KIF1B, MKLN1, NFAT5, NIPBL +7 more | View in SCUBA |
| Macrophages | Epigenetic Remodeling Housekeeping | AFF4, AGO3, AKAP13, ARID4B, ASH1L, CYTH1, ELF1, EPC1 +16 more | View in SCUBA |
| Mucosal-associated invariant T cell | Epigenetic Maintenance DNA/chromatin regulation | ATAD2B, ATXN10, DENND6A, DGLUCY, DMTF1, FYCO1, GALK2, HDLBP +13 more |
About the gene
| Synonyms | FLJ10707, SETD5A |
|---|---|
| Chromosome | 3: 9397615-9479240 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Chromatin regulator, Methyltransferase, Transferase |
| Biological process | Transcription, Transcription regulation |
Function
Chromatin regulator required for brain development: acts as a regulator of RNA elongation rate, thereby regulating neural stem cell (NSC) proliferation and synaptic transmission. May act by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3), which is essential to allow on-time RNA elongation dynamics. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The relevance of histone methyltransferase activity is however subject to discussion
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.