SIGIRR — Single Ig and TIR domain containing
SIGIRR belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SIGIRR's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | TCR Proximal Signaling TCR Signaling | ADGRG5, BIN2, C11orf21, C12orf75, CD300A, FGR, GPSM3, LAT +11 more | |
| Glial cells | MHC-I Antigen Presentation Inflammation | B2M, BTN3A2, C1R, C1S, CST3, HLA-A, HLA-B, HLA-C +4 more | View in SCUBA |
| Innate lymphoid cells | NK Homing Circulating Homing & TEM | ADD3, ANXA1, APOBEC3G, C16orf54, C1orf162, CAPG, CASP4, CAST +37 more | View in SCUBA |
| Mucosal-associated invariant T cell | T cell Surface Signaling TCR Signaling | CD37, ICAM3, LIME1, MFNG, MZT2A, NAA10, PLSCR3 |
About the gene
| Synonyms | IL-1R8, TIR8 |
|---|---|
| Chromosome | 11: 405716-417455 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins |
Function
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor- proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.