NAA10 — N-alpha-acetyltransferase 10, NatA catalytic subunit
NAA10 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NAA10's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Vascular Tone Regulation Endothelial cell development | ADAMTS6, ATP1A1, ATP1B3, ATP5PF, CALD1, CAVIN3, CCDC3, CD81 +13 more | View in SCUBA |
| Gamma-delta T cells | Protein Homeostasis Chaperones Housekeeping | ATXN10, DYNLRB1, GMFG, HIGD1A, POLR2J, PPIA, PPIB, PRDX2 +6 more | |
| Innate lymphoid cells | Endosomal Trafficking Signaling Immune regulation | ARF1, CCDC85B, CKLF, COMMD8, FAM50A, GDE1, HAX1, IL27RA +16 more | View in SCUBA |
| Macrophages | Mitochondrial Biogenesis Mitochondrial & OxPhos | AIMP1, ATP5F1D, ATP5MC1, C1QBP, CCT2, CCT3, CCT7, CHCHD1 +38 more | View in SCUBA |
| Mucosal-associated invariant T cell | T cell Surface Signaling TCR Signaling | CD37, ICAM3, LIME1, MFNG, MZT2A, PLSCR3, SIGIRR |
About the gene
| Synonyms | ARD1, ARD1A, DXS707, TE2 |
|---|---|
| Chromosome | X: 153929225-153935080 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Enzymes, Essential proteins, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Acyltransferase, Transferase |
Function
Catalytic subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase activity. Acetylates amino termini that are devoid of initiator methionine. The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration. Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development. Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX. Acetylates HIST1H4A. Acts as a negative regulator of sister chromatid cohesion during mitosis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.