Cytotoxic Lymphocyte Program
Gene co-expression module in Mucosal-associated invariant T cell
| Category | cytotoxicity |
|---|---|
| Genes | 18 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 18 genes have a known function matching the annotation |
Why this annotation
NKG7 (natural killer granule protein 7, cytotoxic granule marker highly expressed in cytotoxic T and NK cells), LTB (lymphotoxin-B, inflammatory cytokine expressed by lymphocytes), FLT3LG (Flt3 ligand, immune cell development/survival factor), EMP3 (epithelial membrane protein 3, expressed on lymphocytes), S100A10 (calcium-binding/annexin II light chain, expressed in NK/T cells), MYL12A (non-muscle myosin light chain, cytoskeletal), PFN1 (profilin-1, actin polymerization), CDKN2D (p19, CDK4/6 inhibitor), LDHB (lactate dehydrogenase B, metabolic), NDUFA12 (Complex I), ETHE1 (persulfide dioxygenase, mitochondrial), PAXX (non-homologous end joining), CYB5A (cytochrome b5, electron transfer). NKG7 and LTB together with FLT3LG point to a lymphocyte effector/cytotoxic program. As a neighbor module to M106 (which also has GZMM/CST7), these two modules together define the cytotoxic MAIT program.
Genes
ANXA11, CDKN2D, CYB5A, EMP3, ETHE1, FLT3LG, GLIPR2, LDHB, LTB, MYL12A, NDUFA12, NKG7, PAXX, PFN1, PLAC8, S100A10, SH3BGRL3, TBCB
Most correlated modules
- Cytotoxic Effector · correlation 0.90
- T cell Surface Signaling · correlation 0.88
- Leukocyte Housekeeping · correlation 0.87
- Mature Effector MAIT · correlation 0.83
- T cell Homeostasis · correlation 0.81
- Mitochondrial Housekeeping · correlation 0.80
- Cytoskeletal Remodeling Migration · correlation 0.80
- Actin Cytoskeletal Dynamics · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.