Actin Cytoskeletal Remodeling
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Cytoskeletal |
|---|---|
| Genes | 16 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes WDR1 (AIP1/cofilin cofactor), CAP1 (actin capping/severing), WAS (Wiskott-Aldrich syndrome protein, Arp2/3 activator), TUBB (tubulin), DEF6 (Rho GEF), and EVL-related actin regulators define a cytoskeletal remodeling program. CCT5/CCT6A are chaperonin subunits that fold actin and tubulin. LCP2 (SLP-76), SASH3, GIMAP6, and SPN are T cell-specific cytoskeletal/signaling components. CASP1 may reflect inflammasome-linked cytoskeletal changes. Strong coherence with core membership of most genes confirms a tight program of T cell actin cytoskeletal organization.
Genes
ANXA6, CAP1, CASP1, CCT5, CCT6A, DEF6, FGD3, GIMAP6, HNRNPF, KPNB1, LCP2, SASH3, SPN, TUBB, WAS, WDR1
Most correlated modules
- ER Protein Glycosylation · correlation 0.82
- Cellular Housekeeping · correlation 0.80
- Chromatin Remodeling · correlation 0.79
- Lymphocyte Trafficking · correlation 0.78
- ER Stress Response · correlation 0.76
- Chromatin Complex Regulation · correlation 0.73
- Actin Cytoskeletal Dynamics · correlation 0.73
- Antigen Processing · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.