Chromatin Epigenetic Regulation
Gene co-expression module in Mucosal-associated invariant T cell
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 23 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 14 of 23 genes have a known function matching the annotation |
Why this annotation
Hub genes include MPHOSPH8 (HUSH epigenetic silencing complex), PRMT2 (arginine methyltransferase), CHD9 (chromatin helicase), LBR (nuclear envelope/chromatin tethering), PSIP1 (LEDGF chromatin reader), and ATM (DNA damage/genome integrity), alongside T cell identity transcription factors IKZF2 (Helios) and FLI1, and TCR component CD247. This combination points to a chromatin/epigenetic regulation program maintaining T cell identity and genome stability. SLFN5 further supports a T cell quiescence or maturation context. Uniform expression across subsets is consistent with a constitutive chromatin maintenance program in MAIT cells.
Genes
ACAP2, APBB1IP, ARHGAP25, ATM, CD247, CHD9, CLCN3, DDX17, FLI1, IKZF2, LBR, MPHOSPH8, N4BP2L2, PRMT2, PSIP1, PYHIN1, RCSD1, RESF1, S1PR4, SLC4A10, SLFN5, TAOK3, ZNF638
Most correlated modules
- Lymphocyte Survival · correlation 0.85
- Calcium Signal Integration · correlation 0.74
- Histone Modification · correlation 0.73
- Cytoskeletal Migration · correlation 0.70
- NF-κB Immune Survival · correlation 0.68
- Integrin Actin Adhesion · correlation 0.66
- Nuclear regulatory housekeeping · correlation 0.66
- T cell Survival Regulation · correlation 0.63
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.