NFKBID — NFKB inhibitor delta

NFKBID belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

NFKBID's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	AP-1 Immediate Early BCR/AP1/NFKb pathway	BTG2, CD69, CD83, DUSP1, EIF1, FOS, FOSB, JUN +7 more	View in SCUBA
CD4⁺ T cells	NF-kB activation TCR/AP1/NFKb pathway	ADRA2B, CD83, CHD4, CYB5D1, DUSP2, EGR2, EGR3, EGR4 +9 more	View in SCUBA
Endothelial	NF-κB Activation Inflammation	C2CD4B, HSPA6, ICAM5, IER3, MAP3K8, NFKBIA, PMAIP1, PTGS2 +5 more	View in SCUBA
Innate lymphoid cells	ILC Survival Residency Gut residency	ARID4B, BAZ1A, BCL2A1, CD44, CSF2, CTSH, CXCL8, DUSP4 +25 more	View in SCUBA
Macrophages	NF-κB Activation Inflammatory	BCL3, BLOC1S6, CD83, CFLAR, CHMP1B, CNOT2, CSRNP1, CYLD +33 more	View in SCUBA
Mucosal-associated invariant T cell	NF-κB Effector Activation Inflammation	ADGRE5, BCL2A1, CCL20, CCL3, CCL3L3, CCL4, CCL4L2, DUSP10 +10 more
Natural Killer cells	NF-κB Activation Inflammation	ARL5B, BIRC3, CD83, KDM6B, NR4A1, NR4A3, RASGEF1B, REL	View in SCUBA

About the gene

Synonyms	IkappaBNS, IkBNS, TA-NFKBH
Chromosome	19: 35887653-35902303
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins, Transcription factors
Biological process	Inflammatory response

Function

Regulates the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR). May also regulate TCR-induced negative selection of thymocytes

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.