S1PR3 — Sphingosine-1-phosphate receptor 3
S1PR3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
S1PR3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Tissue Resident CD103+ Tissue residence | ADRB1, BCAS4, BLMH, CCNJL, CD160, CD96, CLIC5, CLNK +28 more | |
| Glial cells | TGF-beta ECM Remodeling ECM remodeling | GALNT2, HCFC1R1, ITGB8, LOXL3, PDGFA, RCAN1, SPRY1 | View in SCUBA |
| Natural Killer cells | Tissue-Resident NK Gut residency | ADRB1, CAMK4, GPR34, GPR55, ITGAE, LRRC25, MYO1E, NCR2 +2 more | View in SCUBA |
| Smooth muscle cells | Secondary Response Genes Stress | ABHD2, BCL6, CSRNP1, ECM2, GADD45A, HRH2, LITAF, MAT2A +3 more | View in SCUBA |
About the gene
| Synonyms | bA791O21.3, C9orf108, C9orf47, EDG-3, EDG3, FLJ37523 |
|---|---|
| Chromosome | 9: 88990863-89005155 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
Function
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.