SLIT3 — Slit guidance ligand 3
SLIT3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SLIT3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Subepithelial Fibroblast Identity Developmental | ANGPTL1, APBB1IP, ARHGAP15, CNTN1, CP, ECM2, EFEMP1, FAM107A +12 more | View in SCUBA |
| Pericytes | Quiescent Pericyte State Developmental | ARID5B, C1QTNF1, CPE, HOPX, ITGA7, LPP, MT2A, MTHFD2 +1 more | View in SCUBA |
| Smooth muscle cells | Arteriolar Mural Cells Development | ESAM, FOXS1, GJA4, LINGO1, NDUFA4L2, NGF, OR51E1, OR51E2 +3 more | View in SCUBA |
About the gene
| Synonyms | MEGF5, SLIL2, Slit-3, SLIT1, slit2 |
|---|---|
| Chromosome | 5: 168661733-169301139 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Developmental protein |
| Biological process | Differentiation, Neurogenesis |
Function
May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.