TMEM147 — Transmembrane protein 147
TMEM147 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TMEM147's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | ER-Golgi Trafficking Vesicular traficking | ARL1, CALR, COPE, DNAJC3, EMC7, GDI2, MPG, MYDGF +6 more | View in SCUBA |
| Macrophages | ER Protein Glycosylation Vesicular traficking | AK2, ALG3, ALG5, BABAM1, CKLF, CRELD2, DDOST, DPM3 +21 more | View in SCUBA |
| Smooth muscle cells | Translocon & Proteostasis Housekeeping | ATP6V0E1, CLTA, EIF3F, NOP10, NPC2, PSMA1, SEC61G, ST13 +2 more | View in SCUBA |
About the gene
| Synonyms | MGC1936, NIFIE14 |
|---|---|
| Chromosome | 19: 35545600-35547526 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters |
Function
Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions. Also acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane. Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity. Regulates LBR localization to the nucleus inner membrane.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.