Nuclear Transport
Gene co-expression module in Endothelial
| Category | Housekeeping |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 14 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes RAN and RANBP1 are core components of the Ran GTPase nuclear transport cycle. Supporting genes include SLC25A5 (mitochondrial ADP/ATP translocator), COX8A (mitochondrial complex IV), MRPL51 (mitochondrial ribosome), TIMM10 (mitochondrial import), HMGN1 (chromatin/nuclear), MZT2B (microtubule nucleation), SNRPD3/LSM5 (spliceosome), ALYREF (mRNA export), ILF2 (nuclear RNA binding), BANF1 (nuclear envelope), HAUS1 (augmin complex), TUBB6 (cytoskeleton), CNIH4 (COPII), PPIA (chaperone). The module mixes nuclear transport (RAN/RANBP1/ALYREF/BANF1), mitochondrial (COX8A/MRPL51/SLC25A5/TIMM10), and RNA processing genes. The dominant hub identity is nuclear-cytoplasmic transport via RAN. The mild upregulation in inflammation (UC/CD) and reversal in remission suggests proliferative/metabolic activity. Neighbor context: this module sits alongside cell-cycle and RNA-processing modules, consistent with a general proliferation-associated housekeeping program. The RAN-centered nuclear transport identity is the strongest signal.
Genes
ALYREF, BANF1, CNIH4, COX8A, HAUS1, HMGN1, ILF2, LSM5, MRPL51, MZT2B, PPIA, RAN, RANBP1, SLC25A5, SNRPD3, TIMM10, TUBB6
Most correlated modules
- Nuclear Transport · correlation 0.92
- Spliceosome snRNP Assembly · correlation 0.88
- Respiratory Chain Complex · correlation 0.87
- ER-Golgi Trafficking · correlation 0.86
- Glycolysis Activation · correlation 0.86
- mRNA Splicing · correlation 0.84
- DNA Replication · correlation 0.84
- NF-κB Oxidative Stress · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.