EC Barrier Integrity
Gene co-expression module in Endothelial
| Category | Endothelial cell development |
|---|---|
| Genes | 23 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 23 genes have a known function matching the annotation |
Why this annotation
Hub genes include RAPGEF3 (EPAC1, cAMP-activated Rap1 GEF critical for EC barrier function and junction stability), ADCY4 (adenylyl cyclase 4, expressed in ECs), ABCB1 (P-glycoprotein/MDR1, expressed in barrier ECs), ARHGAP31 (Rho GAP regulating Rac1/Cdc42), PALMD (palmdelphin, EC-expressed), THSD7A (thrombospondin domain, EC marker). The cAMP-EPAC-Rap1 axis (RAPGEF3/ADCY4) is a key regulator of endothelial barrier integrity. Mild downregulation in inflammation with recovery in remission supports a barrier/homeostatic function.
Genes
ABCB1, ADCY4, AQP3, ARHGAP31, CRYBG3, EPS8, FGR, FRYL, GULP1, KLF13, MAST4, MCTP1, PALMD, PIK3C2A, RAPGEF3, RIPK3, SERTAD4, SYNE2, SYNJ2, THSD7A, TM4SF1, TRIM2, ZMIZ2
Most correlated modules
- Arterial EC Identity · correlation 0.91
- EC Inflammatory Activation · correlation 0.87
- Hypoxia-IFN Endothelial · correlation 0.86
- Cytoskeletal Scaffolding · correlation 0.86
- EC Quiescence Identity · correlation 0.84
- Vascular Homeostasis · correlation 0.80
- Endothelial Quiescence · correlation 0.79
- Inflammatory Angiogenic Activation · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.