RECQL — RecQ like helicase
RECQL belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RECQL's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Actin Cytoskeletal Remodeling Cytoskeletal | ACTR2, ANKRD11, ARPC4, CAP1, EIF4G1, FYTTD1, G3BP1, GSPT1 +8 more | View in SCUBA |
| Gamma-delta T cells | DNA Damage Repair DNA/chromatin regulation | AGGF1, ANP32A, DCK, DDX46, HADHA, HDDC2, HENMT1, IFNAR1 +8 more | |
| Macrophages | mRNA Splicing Processing Housekeeping | AP3D1, BAZ1B, CCDC47, CHTOP, CTCF, EIF1AX, EIF3A, HDLBP +29 more | View in SCUBA |
| Mucosal-associated invariant T cell | Mitochondrial Ribosome Mitochondrial & OxPhos | AGTRAP, BRK1, C11orf68, C14orf119, CNPY2, CZIB, DCTPP1, DYNC1I2 +22 more |
About the gene
| Synonyms | RecQ1, RecQL1 |
|---|---|
| Chromosome | 12: 21468910-21501669 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | DNA-binding, Helicase, Hydrolase, Isomerase |
Function
DNA helicase that plays a role in DNA damage repair and genome stability. Exhibits a Mg(2+)- and ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Full-length protein unwinds forked DNA substrates, resolves Holliday junctions, and has DNA strand annealing activity. Plays a role in restoring regressed replication forks. Required to restart stalled replication forks induced by abortive topoisomerase 1 and 2 lesions. Does not unwind G-quadruplex DNA. May play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.