PEA15 — Proliferation and apoptosis adaptor protein 15
PEA15 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PEA15's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B cell activation BCR/AP1/NFKb pathway | ADGRG5, BCAR3, CD86, CLIP2, CNOT2, CTSH, FAS, GABARAPL2 +7 more | View in SCUBA |
| Endothelial | Actomyosin Contractility Cytoskeletal | BCAP29, CAPN2, GNB2, INPP5A, ITPRIPL2, LGALS1, LRRC8C, MPRIP +2 more | View in SCUBA |
| Macrophages | Oxidative Metabolic Program Mitochondrial & OxPhos | ACADM, CA2, CALM3, CAPG, COQ2, CSRP1, CSTB, DENND2D +29 more | View in SCUBA |
| Monocytes | MHC-II Antigen Presentation Innate immunity | HLA-DMA, HLA-DMB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1 +1 more | View in SCUBA |
| Pericytes | RAS Cytoskeletal Signaling Cytoskeletal | ARPC5L, CNDP2, FAM177A1, KLF3, KRAS, LRRFIP1, PTPN12, UBE2J1 | View in SCUBA |
About the gene
| Synonyms | HMAT1, HUMMAT1H, MAT1, MAT1H, PEA-15, PED, PED-PEA15, PED/PEA15 |
|---|---|
| Chromosome | 1: 160205380-160215376 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Biological process | Apoptosis, Sugar transport, Transport |
Function
Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.