SMARCB1 — SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMARCB1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SMARCB1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | IgA plasma cell B cell maturation | AIM2, CD27, CORO1B, IGHA1, IGHA2, JCHAIN, MGAT4A, OSBPL10 +2 more | View in SCUBA |
| Fibroblasts | Metabolic Homeostasis Housekeeping | ADH5, ALDH2, ATP2B1, ISCU, NBL1, NLGN4X, PGM1, PKIG +4 more | View in SCUBA |
| Gamma-delta T cells | Mitochondrial OxPhos Mitochondrial & OxPhos | ADSL, AP1S1, CD151, COMTD1, COX5A, DDT, DNPH1, DUSP23 +20 more | |
| Innate lymphoid cells | ILC1 Lymphocyte Signaling Immune regulation | CDIPT, CNPY3, DBNL, ENG, IL16, LIMD2, LSM2, MAPKAPK3 +11 more | View in SCUBA |
| Macrophages | Low-Coherence Mixed Technical artifact | AAMP, ALKBH7, CDC123, COMMD5, DNTTIP1, EIF3G, EIF4E2, FAM32A +8 more | View in SCUBA |
About the gene
| Synonyms | BAF47, hSNFS, INI-1, Ini1, PPP1R144, RDT, Sfh1p, SNF5, SNF5L1, Snr1 |
|---|---|
| Chromosome | 22: 23786931-23838009 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Disease related genes, Essential proteins, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Activator, Chromatin regulator, DNA-binding |
| Biological process | Cell cycle, Host-virus interaction, Neurogenesis, Transcription, Transcription regulation |
Function
Core component of the BAF (hSWI/SNF) complex. This ATP- dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.