TPM2 — Tropomyosin 2
TPM2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TPM2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Focal Adhesion ECM Migration & adhesion | ACTN1, CLIC4, COL4A1, COL4A2, MPRIP, MRPL33, MYL6, NDUFA4 +6 more | View in SCUBA |
| Pericytes | Smooth Muscle Contractile Cytoskeletal | ACTA2, CSRP1, FLNA, MYL9, MYLK, NEXN, PPP1R14A, S100A4 +2 more | View in SCUBA |
| Smooth muscle cells | SMC contractile apparatus Contractility | ACTA2, ACTB, CALD1, CAV1, DSTN, MYL6, MYL9, PPP1R14A +2 more | View in SCUBA |
About the gene
| Synonyms | AMCD1, DA1, NEM4 |
|---|---|
| Chromosome | 9: 35681992-35690056 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Actin-binding, Muscle protein |
Function
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.