LDLRAD3 — Low density lipoprotein receptor class A domain containing 3
LDLRAD3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LDLRAD3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Wnt Angiogenic Remodeling ECM remodeling | ADAMTS4, ADGRL2, BAZ1A, FKBP11, IL4R, LEF1, MTHFD2, NEURL1B +5 more | View in SCUBA |
| Fibroblasts | Caveolae Mechanosensing Migration & adhesion | CAVIN1, FNBP1, KLHL5, MAP3K20, PDLIM3, PHLDB2, PLEKHO1, PLP2 +6 more | View in SCUBA |
| Innate lymphoid cells | Inflammasome Activation Inflammation | ANKRD28, AP3D1, ARHGEF7, CCNH, CD55, CDC42SE1, CHD7, CHKA +19 more | View in SCUBA |
About the gene
| Synonyms | LRAD3 |
|---|---|
| Chromosome | 11: 35943981-36232136 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
| Molecular function | Receptor |
| Biological process | Host-virus interaction |
Function
May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production. May regulate ITCH and NEDD4 E3 ligase activity and degradation. (Microbial infection) Acts as a receptor for Venezuelan equine encephalitis virus.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.