TCEA1 — Transcription elongation factor A1
TCEA1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TCEA1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Germinal Center Maturation B cell maturation | BCAS4, BCL7A, CCDC69, DCK, DTX1, ITGAE, LSM10, NEIL1 +5 more | View in SCUBA |
| CD4⁺ T cells | RNA & Chromatin Regulation RNA processing | ATRX, DCP2, DIP2A, HNRNPLL, KDM5B, NCOR1, OGDH, RIOK3 +7 more | View in SCUBA |
| Gamma-delta T cells | DNA Damage Repair DNA/chromatin regulation | AGGF1, ANP32A, DCK, DDX46, HADHA, HDDC2, HENMT1, IFNAR1 +8 more | |
| Innate lymphoid cells | Proteasome & COPI Trafficking Protein processing & ER | CCT8, COPE, COPZ1, COX5A, FIBP, GPX4, LAMTOR4, MDH1 +5 more | View in SCUBA |
About the gene
| Synonyms | GTF2S, SII, TCEA, TF2S, TFIIS |
|---|---|
| Chromosome | 8: 53966552-54022456 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Predicted intracellular proteins |
| Molecular function | DNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.