Stress Negative Feedback
Gene co-expression module in Gamma-delta T cells
| Category | Immune regulation |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 16 genes have a known function matching the annotation |
Why this annotation
CYLD (deubiquitinase, linear ubiquitin chain removal, negative regulator of NF-κB), CDKN1A/p21 (cell cycle arrest, stress/activation-induced), DUSP10/MKP5 (MAPK phosphatase, anti-inflammatory), DNAJB6 (HSP40 chaperone, protein quality control), AZIN1 (antizyme inhibitor, polyamine metabolism), INSIG1 (ER-anchored sterol sensor), MIDEAS (MiDAC transcriptional repressor complex), ZFAND2A (stress granule/proteasome-associated), and RASGEF1B (Ras GEF). The module is enriched in negative regulators of inflammatory kinase cascades (CYLD, DUSP10) combined with stress-response and growth-arrest genes (CDKN1A, DNAJB6). Neighboring M87 (NF-κB activation) supports this as a counter-regulatory/negative feedback module.
Genes
ANKRD12, AZIN1, CCDC186, CDKN1A, CYLD, DENND4A, DNAJB6, DUSP10, ELL, GPRIN3, INSIG1, MIDEAS, RASGEF1B, TULP4, ZFAND2A, ZNF267
Most correlated modules
- ER Stress Response · correlation 0.91
- Chromatin Epigenetic Regulation · correlation 0.91
- NF-κB Activation · correlation 0.84
- Pre-mRNA Splicing · correlation 0.84
- hnRNP Splicing Complex · correlation 0.82
- Autophagy Stress Response · correlation 0.82
- TCR Threshold Regulation · correlation 0.79
- Wnt-STAT3 Signaling · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.