MCOLN2 — Mucolipin TRP cation channel 2
MCOLN2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MCOLN2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | BCR Ras signaling BCR/AP1/NFKb pathway | ANKRD28, CCL5, DOK3, GSTK1, GYPC, HOPX, HSH2D, ITGAM +12 more | View in SCUBA |
| CD4⁺ T cells | Th17 lineage Th17 fate | ADA, ARHGEF3, CD226, CD52, DENND3, EVL, IDH2, IL17RE +13 more | View in SCUBA |
| Gamma-delta T cells | NK-like Mature gd-T cytotoxicity | ABHD2, ATG9A, CEP78, HAVCR2, HSH2D, IFIT2, ITGAX, KIR2DL1 +14 more |
About the gene
| Synonyms | FLJ36691, TRP-ML2, TRPML2 |
|---|---|
| Chromosome | 1: 84925583-84997113 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins, Transporters, Voltage-gated ion channels |
| Molecular function | Calcium channel, Ion channel |
| Biological process | Adaptive immunity, Calcium transport, Immunity, Innate immunity, Ion transport, Protein transport, Transport |
Function
Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as a Ca(2+)-permeable cation channel with inwardly rectifying activity. May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6- regulated recycling pathway. May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity). In the innate immune response, may play a role in the regulation of chemokine secretion and macrophage migration (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events. Also functions as a Fe(2+) permeable channel (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.