ITPR3 — Inositol 1,4,5-trisphosphate receptor type 3
ITPR3 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ITPR3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Oxidative Stress Response Stress | AHR, CD151, CD59, CTTNBP2NL, DSTN, FLOT2, GNB4, GNG5 +11 more | View in SCUBA |
| Gamma-delta T cells | Chromatin Remodeling DNA/chromatin regulation | ACTN4, ANP32E, AP2B1, CCDC82, EIF2B1, EXOSC10, FAR1, FLII +17 more |
About the gene
| Synonyms | IP3R3 |
|---|---|
| Chromosome | 6: 33620365-33696574 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Human disease related genes, Plasma proteins, Predicted membrane proteins |
| Molecular function | Calcium channel, Ion channel, Ligand-gated ion channel, Receptor |
| Biological process | Calcium transport, Ion transport, Transport |
Function
Inositol 1,4,5-trisphosphate-gated calcium channel that, upon 1D-myo-inositol 1,4,5-trisphosphate binding, transports calcium from the endoplasmic reticulum lumen to cytoplasm, thus releasing the intracellular calcium and therefore participates in cellular calcium ion homeostasis. 1D-myo-inositol 1,4,5-trisphosphate binds to the ligand-free channel without altering its global conformation, yielding the low-energy resting state, then progresses through resting-to preactivated transitions to the higher energy preactivated state, which increases affinity for calcium, promoting binding of the low basal cytosolic calcium at the juxtamembrane domain (JD) site, favoring the transition through the ensemble of high-energy intermediate states along the trajectory to the fully-open activated state. Upon opening, releases calcium in the cytosol where it can bind to the low-affinity cytoplasmic domain (CD) site and stabilizes the inhibited state to terminate calcium release.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.