PPCS — Phosphopantothenoylcysteine synthetase
PPCS belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PPCS's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | DNA Damage Repair DNA/chromatin regulation | ANKRD10, ASF1A, DDX18, DNAJC17, ENPP5, KLRC4, KLRD1, NARS1 +15 more | |
| Innate lymphoid cells | Centrosome & Scaffolding Cytoskeleton & motility | AKAP9, APPL1, ARID4A, CCDC91, CPNE3, ETNK1, FAM204A, GOPC +14 more | View in SCUBA |
| Lymphatic endothelial | Metabolic Housekeeping Housekeeping | CAPNS1, CYB5R3, DMAC1, DUT, EID1, ESD, GNAI2, ISCU +5 more | View in SCUBA |
| Macrophages | ER Protein Glycosylation Vesicular traficking | AK2, ALG3, ALG5, BABAM1, CKLF, CRELD2, DDOST, DPM3 +21 more | View in SCUBA |
About the gene
| Synonyms | FLJ11838 |
|---|---|
| Chromosome | 1: 42456117-42473385 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Ligase |
Function
Catalyzes the second step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. Has a preference for ATP over CTP as a cosubstrate.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.