SBDS — SBDS ribosome maturation factor
SBDS belongs to a gene co-expression module in 12 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SBDS's module in each cell type
About the gene
| Synonyms | CGI-97, FLJ10917, SDO1, SDS, SWDS |
|---|---|
| Chromosome | 7: 66987680-66995693 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Disease related genes, Essential proteins, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Biological process | Ribosome biogenesis |
Function
Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.