Macrophage Migration
Gene co-expression module in Macrophages
| Category | Migration & adhesion |
|---|---|
| Genes | 21 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 21 genes have a known function matching the annotation |
Why this annotation
Hub genes include EPS8 (actin barbed-end capping, lamellipodia, EGFR signaling), RAPH1/lamellipodin (actin polymerization at leading edge, cell migration), ITGA9 (integrin alpha-9, adhesion/migration), CEMIP2 (cell migration-inducing protein), RHOBTB1 (atypical Rho GTPase), MEF2C (macrophage identity transcription factor), NFIA (transcription factor), CPM (carboxypeptidase M, monocyte/macrophage surface marker), SGMS1 (sphingomyelin synthase, membrane lipids), SESN1 (sestrin, stress/mTOR). The strongest theme is macrophage migration and adhesion: EPS8, RAPH1, ITGA9, CEMIP2, RHOBTB1 all directly support cell motility and cytoskeletal dynamics in the context of macrophage tissue infiltration. CPM and MEF2C confirm macrophage identity. Enrichment in mono_mac for CPM, CEMIP2, GBE1 is consistent.
Genes
CEMIP2, CPM, EPB41L2, EPS8, GBE1, ITGA9, KCNQ1, MAN1A1, MEF2C, MVB12B, NFIA, PDGFC, PPP1R21, RAPH1, RHOBTB1, SEL1L3, SESN1, SGMS1, SLC9A9, TBC1D14, ZDHHC14
Most correlated modules
- Rho GTPase Signaling · correlation 0.95
- Endosomal Rab Trafficking · correlation 0.95
- MITF Lysosomal Program · correlation 0.93
- Transcriptional Regulation · correlation 0.93
- Chromatin Remodeling · correlation 0.93
- DNA Damage Response · correlation 0.93
- Golgi Vesicle Trafficking · correlation 0.91
- Transcriptional Kinase Regulation · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.