UGGT1 — UDP-glucose glycoprotein glucosyltransferase 1
UGGT1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
UGGT1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Chromatin Epigenetic Regulation DNA/chromatin regulation | ACIN1, ASH1L, BDP1, BLTP1, CLTC, EPS15, EXOC2, FAM120B +24 more | |
| Macrophages | TGF-beta Signaling Inflammatory | APPL1, BBX, C6orf89, CCDC50, CREB3L2, HCLS1, NCKAP1L, NFIC +9 more | View in SCUBA |
About the gene
| Synonyms | HUGT1, UGCGL1 |
|---|---|
| Chromosome | 2: 128091200-128195677 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Glycosyltransferase, Transferase |
Function
Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.