Type I Interferon
Gene co-expression module in Macrophages
| Category | Antiviral |
|---|---|
| Genes | 22 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 20 of 22 genes have a known function matching the annotation |
Why this annotation
This module is a textbook type I interferon response signature: IFIT1/2/3 (interferon-induced tetratricopeptide repeat proteins), MX1/MX2 (dynamin-like GTPases, antiviral), OAS1/2/3 (oligoadenylate synthetases, dsRNA sensors), ISG15 (ubiquitin-like ISG), RSAD2 (viperin, antiviral lipid metabolism), RIGI (cytosolic RNA sensor), IFI44/IFI44L, IFI6, OASL, ISG20 (exonuclease), IRF7 (master IFN transcription factor), CMPK2, LY6E, HELZ2. All genes are canonical ISGs. Enriched in mono_mac. Neighbor M120 extends this program with sensors and effectors.
Genes
CCL8, CMPK2, HELZ2, IFI27, IFI44, IFI44L, IFI6, IFIT1, IFIT2, IFIT3, IRF7, ISG15, ISG20, LY6E, MX1, MX2, OAS1, OAS2, OAS3, OASL, RIGI, RSAD2
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.