Wnt/AP-1 Activation
Gene co-expression module in Monocytes
| Category | Inflammatory |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 11 genes have a known function matching the annotation |
Why this annotation
CTNNB1 (beta-catenin) is a central Wnt signaling effector and transcriptional co-activator. FOSL2 (Fra-2) is an AP-1 transcription factor downstream of Wnt/MAPK. GABARAPL1 is an autophagy receptor. ETF1 is a translation termination factor. CHD1 is a chromatin remodeler. B4GALT1 is involved in glycosylation. GPCPD1 is a glycerophosphocholine phosphodiesterase. PNPLA8 is a mitochondrial phospholipase. TENT4B is an mRNA poly(A) polymerase. BZW1 and SYAP1 are translational regulators. The module shows moderate upregulation in IBD inflammation with reversal in remission. The combination of CTNNB1, FOSL2, and chromatin/mRNA regulatory genes suggests a Wnt/AP-1 transcriptional activation program in inflammatory monocytes, possibly linked to tissue remodeling signaling.
Genes
B4GALT1, BZW1, CHD1, CTNNB1, ETF1, FOSL2, GABARAPL1, GPCPD1, PNPLA8, SYAP1, TENT4B
Most correlated modules
- Hypoxia Response · correlation 0.77
- TREM1 Inflammatory Signaling · correlation 0.76
- NLRP3 Inflammasome Activation · correlation 0.75
- Complement Receptor Activation · correlation 0.73
- AMPK-FOXO Stress Response · correlation 0.69
- Inflammatory Metabolic Reprogramming · correlation 0.59
- G-protein Membrane Remodeling · correlation 0.58
- Integrated Stress Response · correlation 0.56
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.