Immature Granulocyte Progenitor
Gene co-expression module in Neutrophils
| Category | Developmental |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 12 genes have a known function matching the annotation |
Why this annotation
ZBTB16 (PLZF) is a zinc finger transcription factor essential for granulopoiesis and early myeloid differentiation; it marks immature granulocyte progenitors and is a master regulator of neutrophil development. MAOA (monoamine oxidase A) is expressed in early myeloid cells and metabolizes biogenic amines. ACSL4 activates arachidonic acid for incorporation into phospholipids and is involved in lipid mediator production and ferroptosis — relevant to activated/differentiating neutrophils. HRH2 (histamine receptor H2) modulates neutrophil function downstream of histamine. AVIL (advillin) is an actin-binding protein. AMPH (amphiphysin) is involved in membrane tubulation. CDC123 supports translation initiation. The low expression (0.377) and detection rate (20.7%) suggest an immature/progenitor neutrophil subpopulation marked by ZBTB16.
Genes
ACSL4, AMPH, AVIL, CDC123, ENSG00000282804, HAL, HRH2, MAOA, MPZL1, NUDT5, ZBTB16, ZNF608
Most correlated modules
- Freshly infiltrated neutrophils · correlation 0.94
- ER Stress Response · correlation 0.91
- TLR5 Bacterial Sensing · correlation 0.91
- Granulopoiesis Transcriptional · correlation 0.88
- PI3K Migration Signaling · correlation 0.88
- Stress Kinase Signaling · correlation 0.85
- Endosomal Vesicle Trafficking · correlation 0.85
- Endosomal Vesicle Trafficking · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.