RALB — RAS like proto-oncogene B
RALB belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RALB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Innate lymphoid cells | Endosomal Trafficking Signaling Immune regulation | ARF1, CCDC85B, CKLF, COMMD8, FAM50A, GDE1, HAX1, IL27RA +16 more | View in SCUBA |
| Pericytes | G1 Cell Cycle Entry Cell cycle | CCND3, CCNY, CPNE8, FKBP9, GRAMD1A, LIPA, MAPK3, MGAT1 +6 more | View in SCUBA |
About the gene
| Chromosome | 2: 120240064-120294710 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins, RAS pathway related proteins |
| Molecular function | Hydrolase |
| Biological process | Apoptosis, Cell cycle, Cell division |
Function
Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis. In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission. Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.