BEST4 Colonocyte Identity
Gene co-expression module in Colonocytes
| Category | Epithelial development |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 26 genes have a known function matching the annotation |
Why this annotation
Hub genes CTSE (cathepsin E, highly enriched in BEST4 colonocytes 4.7x), GNAI2 (G-protein alpha-i2, BEST4 3.4x), ADCY7 (adenylyl cyclase 7, BEST4 5.1x), OSBPL8 (oxysterol binding, BEST4 2.4x), ATP2B4 (plasma membrane Ca2+ ATPase, BEST4 3.4x), GALNT6 (O-glycosylation, BEST4 2.2x), NAB1 (BEST4 2.3x), LYZ (lysozyme), TMEM176A/B (inflammation-associated), and CCPG1 (ER-phagy receptor) define a BEST4 colonocyte-specific program. BEST4 cells are specialized electrolyte-sensing colonocytes expressing BEST4 chloride channels. The adenylyl cyclase/G-protein signaling axis is consistent with their role in sensing luminal signals. Despite being a neighbor to inf_colono-enriched modules, this module is primarily BEST4-specific.
Genes
Most correlated modules
- Inflammasome Activation · correlation 0.74
- BEST4+ Colonocyte Identity · correlation 0.70
- Secretory Differentiation · correlation 0.69
- BEST4 Colonocyte Identity · correlation 0.55
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.