Protein Biogenesis
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 32 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 14 of 32 genes have a known function matching the annotation |
Why this annotation
EIF4G1 (eukaryotic translation initiation factor 4G1) is the top hub, supporting a translation/protein biogenesis theme. DNAJA2 and DNAJC21 are HSP40-family chaperones involved in protein folding. VCP (p97/CDC48) is a central AAA-ATPase for protein quality control and ER-associated degradation (ERAD). SEC61A1 is the core ER translocon subunit. EFTUD2 and DDX46 are spliceosomal components. TARS1 is threonyl-tRNA synthetase. ATP6V0D1 is a V-ATPase subunit. B3GAT3 is involved in proteoglycan biosynthesis. OTUB1 is a deubiquitinase. The module spans translation initiation, ER translocation, protein folding, and splicing — broad protein biogenesis housekeeping. Neighbor context (M3 = ER processing, M63 = RNA processing) supports this as part of a coordinated protein synthesis neighborhood.
Genes
ATP6V0D1, B3GAT3, BUD23, C11orf58, CHD4, CNPY2, DAZAP1, DDX46, DNAJA2, DNAJC21, EFTUD2, EIF4G1, FLII, HNRNPA0, IDH3B, IK, KRR1, LSM8, LYRM2, MLX, MOB4, OTUB1, RNF126, SEC61A1, TARS1, TGS1, TRIR, UBA1, UBE2I, VCP, YKT6, ZMAT2
Most correlated modules
- RNA Processing & Repair · correlation 0.98
- Actin Cytoskeleton Organization · correlation 0.96
- RNA Splicing Regulation · correlation 0.95
- ER Protein Processing · correlation 0.95
- Proteasome UPS · correlation 0.95
- Mixed Housekeeping · correlation 0.94
- mRNA Splicing Processing · correlation 0.94
- Mitochondrial Housekeeping · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.