NFKBIB — NFKB inhibitor beta
NFKBIB belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NFKBIB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Effector activation NFkB TCR/AP1/NFKb pathway | ADAM19, AHR, ARFGAP3, ATF5, BHLHE40, CGAS, DUSP5, ETF1 +23 more | View in SCUBA |
| Gamma-delta T cells | Heat Stress Apoptotic Stress | AMD1, DBF4, DNAJB9, DUSP2, IER5, NINJ1, PHLDA1, PMAIP1 +5 more | |
| Lymphatic endothelial | NF-κB Autophagy Regulation Immune regulation | CLIC2, GABARAPL1, LGMN, OSER1, PRRG4, RELB, RNF114, SQSTM1 +3 more | View in SCUBA |
| Macrophages | Lipid-Sensing Transcriptional Lipid metabolism | ANKLE2, BAIAP2, C19orf25, C1orf52, COX19, CWC25, DEDD2, DNTTIP2 +29 more | View in SCUBA |
| Mucosal-associated invariant T cell | NF-κB Negative Feedback Immune regulation | ARL4A, BCAS2, CSRNP1, CXCR4, ENSG00000285976, IDS, ITPRIP, NFKBIA +7 more |
About the gene
| Synonyms | IKBB, TRIP9 |
|---|---|
| Chromosome | 19: 38899700-38908893 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
Function
Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.