MAIT Tissue Residence
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Tissue residence |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 16 genes have a known function matching the annotation |
Why this annotation
CXCR6 is the defining chemokine receptor for MAIT cell tissue residence and gut/liver homing. CD3E and CD53 are pan-T/immune surface markers. LPXN (leupaxin) mediates integrin-dependent adhesion relevant to tissue retention. TAP1 and GBP5 reflect interferon-induced antigen processing. CTSD (cathepsin D) and OSTF1 link to lysosomal activity. ECH1 and ATP5IF1 reflect mitochondrial metabolic activity typical of tissue-resident cells. RGS14 modulates G-protein/chemokine receptor signaling. The moderate coherence reflects a mixed but MAIT tissue-residence-centered program. Neighbor context (cytoskeletal M52, ER M135) is consistent with a functional MAIT cell-state module rather than an artifact.
Genes
ANAPC16, ARHGDIB, ATP5IF1, CD3E, CD53, CD99, CTSD, CXCR6, ECH1, EVL, GBP5, LPXN, OSTF1, PRR5, RGS14, TAP1
Most correlated modules
- Mitochondrial Metabolism & Redox · correlation 0.81
- Antigen Processing · correlation 0.79
- ER Stress Response · correlation 0.79
- Cellular Housekeeping · correlation 0.73
- Type I Interferon · correlation 0.73
- ATP Synthase Complex · correlation 0.72
- Actin Cytoskeletal Remodeling · correlation 0.67
- ER Protein Glycosylation · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.