NOL7 — Nucleolar protein 7

NOL7 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

NOL7's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Membrane trafficking Housekeeping	BCL2, CLSTN1, GLB1, GTF2I, HPSE, HSDL2, LENG8, MBIP +19 more	View in SCUBA
Innate lymphoid cells	TRiC Chaperonin Folding Protein processing & ER	ATP6V0D1, CACYBP, CCT2, CCT3, CCT4, CCT5, EIF5A, ELOC +9 more	View in SCUBA
Macrophages	Mixed Housekeeping Housekeeping	AP2M1, BAG1, CHMP4A, CISD2, COA6, CSNK2B, CYB5R3, DEGS1 +20 more	View in SCUBA

About the gene

Synonyms	C6orf90, dJ223E5.2, NOP27, PQBP3, RARG-1
Chromosome	6: 13615335-13632739
Predicted location	Intracellular
Essential gene	Yes
Protein class	Essential proteins, Predicted intracellular proteins
Biological process	Ribosome biogenesis

Function

Functions as part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit that coordinates the first two steps of ribosome biogenesis in transcription of the primary transcript pre-RNA and pre-18S processing. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre- ribosomal RNA by the RNA exosome. This subunit is required for processing of the 5'-external transcribed spacer sequence (5'ETS) of the primary transcript pre-rRNA to yield the 18S rRNA. Also plays a role in maintaining early pre-rRNA levels, either by assisting in its transcription or stability.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.