SPINT2 — Serine peptidase inhibitor, Kunitz type 2
SPINT2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SPINT2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | RNA processing RNA processing | AARSD1, ABHD14A, AMD1, CALM2, CDKN2AIP, CHMP1B, FRAT1, HNRNPAB +7 more | View in SCUBA |
| Enterocytes | Lysosomal/ferritin housekeeping Housekeeping | APLP2, CD164, CRIP1, CST3, EDF1, FTH1, FTL, GPA33 +5 more | View in SCUBA |
| Gamma-delta T cells | Immature T Cell T cell maturation | A1BG, ACP5, CD38, CD7, ID3, ITM2C, MZB1, NCF1 +7 more | |
| Monocytes | MHC-II Antigen Presentation Innate immunity | HLA-DMA, HLA-DMB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1 +1 more | View in SCUBA |
About the gene
| Synonyms | HAI-2, HAI2, Kop |
|---|---|
| Chromosome | 19: 38244035-38292615 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Protease inhibitor, Serine protease inhibitor |
Function
Inhibitor of HGFAC. Also inhibits plasmin, and plasma and tissue kallikrein. Inhibits serine protease activity of TMPRSS13. Inhibits serine protease activity of ST14/matriptase and PRSS8/prostasin in vitro.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.